Introduction to Theoretical Population Genetics / by Thomas Nagylaki
(Biomathematics ; 21)
| データ種別 | 電子ブック |
|---|---|
| 出版者 | Berlin, Heidelberg : Springer Berlin Heidelberg |
| 出版年 | 1992 |
| 本文言語 | 英語 |
| 大きさ | XII, 369 p : online resource |
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| 内容注記 | 1. Introduction 2. Asexual Haploid Populations 2.1 Selection 2.2 Mutation and Selection 2.3 Migration and Selection 2.4 Continuous Model with Overlapping Generations 2.5 Random Drift 2.6 Problems 3. Panmictic Populations 3.1 The Hardy-Weinberg Law 3.2 X-Linkage 3.3 Two Loci 3.4 Population Subdivision 3.5 Genotypic Frequencies in a Finite Population 3.6 Problems 4. Selection at an Autosomal Locus 4.1 Formulation for Multiple Alleles 4.2 Dynamics with Two Alleles 4.3 Dynamics with Multiple Alleles 4.4 Two Alleles with Inbreeding 4.5 Variable Environments 4.6 Intra-Family Selection 4.7 Maternal Inheritance 4.8 Meiotic Drive 4.9 Mutation and Selection 4.10 Continuous Model with Overlapping Generations 4.11 Density and Frequency Dependence 4.12 Problems 5. Nonrandom Mating 5.1 Selfing with Selection 5.2 Assortative Mating with Multiple Alleles and Distinguishable Genotypes 5.3 Assortative Mating with Two Alleles and Complete Dominance 5.4 Random Mating with Differential Fertility 5.5 Self-Incompatibility Alleles 5.6 Pollen and Zygote Elimination 5.7 Problems 6. Migration and Selection 6.1 The Island Model 6.2 General Analysis 6.3 The Levene Model 6.4 Two Diallelic Niches 6.5 Problems 7. X-Linkage 7.1 Formulation for Multiallelic Selection and Mutation 7.2 Selection with Two Alleles 7.3 Mutation-Selection Balance 7.4 Weak Selection 7.5 Problems 8. Two Loci 8.1 General Formulation for Multiple Loci 8.2 Analysis for Two Multiallelic Loci 8.3 Two Diallelic Loci 8.4 Continuous Model with Overlapping Generations 8.5 Problems 9. Inbreeding and Random Drift 9.1 The Inbreeding Coefficient 9.2 Calculation of the Inbreeding Coefficient from Pedigrees 9.3 Identity Relations Between Relatives 9.4 Phenotypic Effects of Inbreeding 9.5 Regular Systems of Inbreeding 9.6 Panmixia in Finite Populations 9.7 Heterozygosity under Mutation and Random Drift 9.8 The Inbreeding Effective Population Number 9.9 The Model for Random Drift of Gene Frequencies 9.10 Random Drift of Gene Frequencies 9.11 Gene-Frequency Change due to Mutation and Random Drift 9.12 The Island Model 9.13 The Variance Effective Population Number 9.14 Problems 10. Quantitative Genetics 10.1 The Decomposition of the Variance with Panmixia 10.2 The Correlation Between Relatives with Panmixia 10.3 The Change in Variance due to Assortative Mating 10.4 The Correlation Between Relatives with Assortative Mating 10.5 Selection 10.6 Mutation-Selection Balance 10.7 Problems References Author Index |
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| 一般注記 | This book covers those areas of theoretical population genetics that can be investigated rigorously by elementary mathematical methods. I have tried to formulate the various models fairly generally and to state the biological as sumptions quite explicitly. I hope the choice and treatment of topics will en able the reader to understand and evaluate detailed analyses of many specific models and applications in the literature. Models in population genetics are highly idealized, often even over idealized, and their connection with observation is frequently remote. Further more, it is not practicable to measure the parameters and variables in these models with high accuracy. These regrettable circumstances amply justify the use of appropriate, lucid, and rigorous approximations in the analysis of our models, and such approximations are often illuminating even when exact solu tions are available. However, our empirical and theoretical limitations justify neither opaque, incomplete formulations nor unconvincing, inadequate analy ses, for these may produce uninterpretable, misleading, or erroneous results. Intuition is a principal source of ideas for the construction and investigation of models, but it can replace neither clear formulation nor careful analysis. Fisher (1930; 1958, pp. x, 23-24, 38) not only espoused similar ideas, but he recognized also that our concepts of intuition and rigor must evolve in time. The book is neither a review of the literature nor a compendium of results. The material is almost entirely self-contained. The first eight chapters are a thoroughly revised and greatly extended version of my published lecture notes (Nagylaki, 1977a) |
| 著者標目 | *Nagylaki, Thomas author SpringerLink (Online service) |
| 件 名 | LCSH:Life sciences LCSH:Bioinformatics LCSH:Computational biology LCSH:Biomathematics FREE:Life Sciences FREE:Computer Appl. in Life Sciences FREE:Mathematical and Computational Biology |
| 分 類 | DC23:570.285 |
| 巻冊次 | ISBN:9783642762147 
|
| ISBN | 9783642762147 |
| URL | http://dx.doi.org/10.1007/978-3-642-76214-7 |
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