Design and Analysis of Vaccine Studies / by M. Elizabeth Halloran, Ira M. Longini, Claudio J. Struchiner
(Statistics for Biology and Health)
| データ種別 | 電子ブック |
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| 出版情報 | New York, NY : Springer New York : Imprint: Springer , 2010 |
| 本文言語 | 英語 |
| 大きさ | XVIII, 390 p : online resource |
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| 内容注記 | and Examples Overview of Vaccine Effects and Study Designs Immunology and Early Phase Trials Binomial and Stochastic Transmission Models and Deterministic Models Evaluating Protective Effects of Vaccination Modes of Action and Time-Varying VE Further Evaluation of Protective Effects Vaccine Effects on Post-Infection Outcomes Household-Based Studies Analysis of Households in Communities Analysis of Independent Households Assessing Indirect, Total, and Overall Effects Randomization and Baseline Transmission Surrogates of Protection |
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| 一般注記 | Widespread immunization has many different kinds of effects in individuals and populations, including in the unvaccinated individuals. The challenge is in understanding and estimating all of these effects. This book presents a unified conceptual framework of the different effects of vaccination at the individual and at the population level. The book covers many different vaccine effects, including vaccine efficacy for susceptibility, for disease, for post-infection outcomes, and for infectiousness. The book includes methods for evaluating indirect, total and overall effects of vaccination programs in populations. Topics include household studies, evaluating correlates of immune protection, and applications of casual inference. Material on concepts of infectious disease epidemiology, transmission models, casual inference, and vaccines provides background for the reader. This is the first book to present vaccine evaluation in this comprehensive conceptual framework. This book is intended for colleagues and students in statistics, biostatistics, epidemiology, and infectious diseases. Most essential concepts are described in simple language accessible to epidemiologists, followed by technical material accessible to statisticians. M. Elizabeth Halloran and Ira Longini are professors of biostatistics at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. Claudio Struchiner is professor of epidemiology and biostatistics at the Brazilian School of Public Health of the Oswaldo Cruz Foundation in Rio de Janeiro. The authors are prominent researchers in the area. Halloran and Struchiner developed the study designs for dependent happenings to delineate indirect, total, and overall effects. Halloran has made contributions at the interface of epidemiological methods, causal inference, and transmission dynamics. Longini works in the area of stochastic processes applied to epidemiological infectious disease problems, specializing in the mathematical and statistical theory of epidemics. Struch iner has contributed to understanding the role of transmission in interpreting vaccine effects |
| 著者標目 | *Halloran, M. Elizabeth author Longini, Ira M. author Struchiner, Claudio J. author SpringerLink (Online service) |
| 件 名 | LCSH:Medicine LCSH:Health informatics LCSH:Infectious diseases LCSH:Epidemiology LCSH:Statistics FREE:Medicine & Public Health FREE:Health Informatics FREE:Epidemiology FREE:Infectious Diseases FREE:Statistics for Life Sciences, Medicine, Health Sciences |
| 分 類 | DC23:502.85 |
| 巻冊次 | ISBN:9780387686363 
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| ISBN | 9780387686363 |
| URL | http://dx.doi.org/10.1007/978-0-387-68636-3 |
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