Mathematical and Statistical Methods for Genetic Analysis / by Kenneth Lange
(Statistics for Biology and Health)
| データ種別 | 電子ブック |
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| 出版情報 | New York, NY : Springer New York : Imprint: Springer , 1997 |
| 本文言語 | 英語 |
| 大きさ | XII, 265 p : online resource |
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| 内容注記 | 1 Basic Principles of Population Genetics 2 Counting Methods and the EM Algorithm 3 Newton’s Method and Scoring 4 Hypothesis Testing and Categorical Data 5 Genetic Identity Coefficients 6 Applications of Identity Coefficients 7 Computation of Mendelian Likelihoods 8 The Polygenic Model 9 Markov Chain Monte Carlo Methods 10 Reconstruction of Evolutionary Trees 11 Radiation Hybrid Mapping 12 Models of Recombination 13 Poisson Approximation Appendix: Molecular Genetics in Brief A.l Genes and Chromosomes A.2 From Gene to Protein A.3 Manipulating DNA A.4 Mapping Strategies References |
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| 一般注記 | During the past decade, geneticists have constructed detailed maps of the human genome and cloned scores of Mendelian disease genes. They now stand on the threshold of sequencing the genome in its entirety. The unprecedented insights into human disease and evolution offered by mapping and sequencing will transform medicine and agriculture. This revolution depends vitally on the contributions of applied mathematicians, statisticians, and computer scientists. Mathematical and Statistical Methods for Genetic Analysis is written to equip graduate students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand in hand with applications to gene mapping, risk prediction, and the testing of epidemiological hypotheses. The book includes many topics currently accessible only in journal articles, including pedigree analysis algorithms, Markov chain Monte Carlo methods, reconstruction of evolutionary trees, radiation hybrid mapping, and models of recombination. Exercise sets are included. Kenneth Lange is Professor of Biostatistics and Mathematics and the Pharmacia & Upjohn Foundations Research Professor at the University of Michigan. He has held visiting appointments at MIT and Harvard. His research interests include human genetics, population modeling, biomedical imaging, computational statistics, and applied stochastic processes |
| 著者標目 | *Lange, Kenneth author SpringerLink (Online service) |
| 件 名 | LCSH:Statistics LCSH:Human genetics LCSH:Biomathematics FREE:Statistics FREE:Statistical Theory and Methods FREE:Mathematical and Computational Biology FREE:Human Genetics |
| 分 類 | DC23:519.5 |
| 巻冊次 | ISBN:9781475727395 
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| ISBN | 9781475727395 |
| URL | http://dx.doi.org/10.1007/978-1-4757-2739-5 |
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