Design and Analysis of DNA Microarray Investigations / by Richard M. Simon, Edward L. Korn, Lisa M. McShane, Michael D. Radmacher, George W. Wright, Yingdong Zhao
(Statistics for Biology and Health)
| データ種別 | 電子ブック |
|---|---|
| 出版者 | New York, NY : Springer New York |
| 出版年 | 2003 |
| 本文言語 | 英語 |
| 大きさ | X, 200 p. 58 illus., 19 illus. in color : online resource |
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| 内容注記 | DNA Microarray Technology Design of DNA Microarray Experiments Image Analysis Quality Control Array Normalization Class Comparison Class Prediction Class Discovery |
|---|---|
| 一般注記 | This book is targeted to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projects. State-of-the-art analysis methods are presented with minimal mathematical notation and a focus on concepts. This book is unique because it is authored by statisticians at the National Cancer Institute who are actively involved in the application of microarray technology. Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands on experience in data analysis, it includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is freely available from the National Cancer Institute for non-commercial use. The authors are current or former members of the Biometric Research Branch at the National Cancer Institute. They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools |
| 著者標目 | *Simon, Richard M. author Korn, Edward L. author McShane, Lisa M. author Radmacher, Michael D. author Wright, George W. author Zhao, Yingdong author SpringerLink (Online service) |
| 件 名 | LCSH:Medicine LCSH:Cancer research LCSH:Molecular biology LCSH:Pharmacology LCSH:Health informatics LCSH:Bioinformatics LCSH:Statistics FREE:Biomedicine FREE:Cancer Research FREE:Bioinformatics FREE:Statistics for Life Sciences, Medicine, Health Sciences FREE:Molecular Medicine FREE:Pharmacology/Toxicology FREE:Health Informatics |
| 分 類 | DC23:614.5999 |
| 巻冊次 | ISBN:9780387218663 
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| ISBN | 9780387218663 |
| URL | http://dx.doi.org/10.1007/b97583 |
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